Fully automated [18F]FAZA production on AllInOne at commercial scale.
Tumor hypoxia is a common feature of many solid malignant tumors. Hypoxic cells are known to be more than three times more resistant than those with normal oxygenation levels. It’s believed that hypoxia associated with malignant progression leads to an increase of the tumor invasive potential. The identification and quantification of such type of tumors will thus improve the monitoring and treatment of this kind of tumors. Many radio tracers have been used to diagnosis this type of tumors including [18F]FRP-170, [18F]FETNIM, [18F]FETA, [18F]FMISO and [18F]FAZA (1). The latter two are the most commonly used tracer for tumor hypoxia, although [18F]-FAZA gives much better images with very high contrast due to its quick clearance from blood and non-target tissue (3).
There is thus a strong need for an efficient fully automated method to match the needs of the market to this marker. We present hereby a fully automated method to produce [18F]-FAZA with high reproducible yield.
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